This can derail your best efforts..

Published: Mon, 04/25/16

 Hi

Stress can hold back even the most perfect health and fitness plan.

Learning how our bodies respond to stress is the first step to combating it.

It is a long read so settle in for the ride...
 Ten Intro Facts About Cortisol

  1. Cortisol is a powerful steroid hormone made in the adrenal cortex of the adrenal glands which sit on the top of each kidney. It is released into the blood in which it then travels all around the body in various amounts depending on various factors such as  the time of day and stress levels.

  2. Almost every cell in the body contains cortisol receptors so cortisol can have lots of different actions depending on which sorts of cells it is acting upon - e.g. blood sugar level control which regulates metabolism, it can be anti-inflammatory, salt and water control (blood pressure), memory formation and even foetal development and triggering the birth process - basically  it is crucial for giving Life and for our very survival!

  3. Cortisol levels are generally higher in the morning at about 7- 8am and fall gradually throughout the day to low levels, reaching their lowest at about 3-4am. This is why they say exercise in the morning is better when your cortisol levels are at their highest- well, at least they should be.

  4. Cortisol release is controlled by a negative feedback loop which  involves the Hypothalamus (the Big Boss Man), the Pituitary (Middle Management) and the adrenal glands (the Workers), otherwise known as the HPA axis.....
 So the negative feedback loop story might go like this:

 Mr/s Stress comes along yelling his/her head off.
  • Your hypothalamus releases corticotrophin-releasing hormone (CRH), which sends a message to the pituitary gland.
  • Pituitary gland release Adrenocorticotrophic Hormone (ACTH) to tell the adrenals to get a move on and release cortisol.
  • Cortisol is released which prepares your body for the high energy "fight or flight" response that it is anticipating. This involves raising blood sugar levels. The adrenals also release adrenaline which raises your heart rate and increases your blood pressure.
  • These interactions continue until your hormones reach the levels that your body perceive it needs. This perception varies and is affected by such thing as how much stress you have had in your life already, how well you handle stress, how sensitive you are etc.
  • After the big telling off, Mr/s Stress leaves the room and then a series of chemical reactions then begins to switch these stress response interactions off - starting with the high levels of cortisol inhibiting further release of CRH and ACTH. It's the negative feedback loop, the brain is detecting there is enough cortisol floating around now, let's stop. The adrenals have done their job well, cortisol and adrenalin ebb, heart rate and blood pressure go down - phew.
  • All back to normal now as the body recovers until the next stress.
Isn't it amazing how Nature has provided us with this protective negative feedback loop mechanism to actually get by?!

5) Alas, for  this good story, there is a bit of a sad ending sometimes. Like insulin resistance, there can also be a cortisol resistance, otherwise known as HPA Axis Dysfunction. When cortisol is chronically overproduced (we are talking years here) the HPA axis eventually becomes desensitised to the negative feedback and cortisol is constantly produced. This leads to chronic stress on the hypothalamus, pituitary gland and adrenal glands and eventually can lead to the nasty situation we know as:

Adrenal Fatigue.... 21st Century Syndrome

In 1998, a Dr James L. Wilson coined the term coined the term ‘adrenal fatigue’ to identify a specific kind of chronic tiredness that many people experience. It can affect anyone who undergoes frequent, persistent or severe mental, emotional or physical stress. He wrote a book titled: "Adrenal Fatigue: The 21st Century Stress Syndrome" and I like it.

Adrenal fatigue is a biggie in complementary medicine circles. Other practitioners might refer to it as "adrenal Insufficiency" and in conventional medicine it seems they don't care much for it at all. Mainstream practitioners are really (and rightfully owing to the severity of the conditions) only concerned with extreme dysfunctions of the adrenals i.e. too much cortisol = Cushing's syndrome and too little or none = Addison's disease.  They will run a blood test for these at one point of the day. At any point, cortisol will be very high or very low/near negligent.
In my case I would run what is called an Adrenal Stress Index (ASI) which involves the patient collecting  four samples of saliva in a little tub at four times throughout the day usually 8am 12pm, 4pm and 8pm. This is tested in the lab and we can see at what times of the day the cortisol levels are literally  out of whack (figure 1), what stage of adrenal fatigue they are in and also what can be done (this is crucial as you don't want to be stimulating the adrenals further if they are already putting large amounts of cortisol out and don't want to be calming them down when they are on their way to exhaustion. The aim of the game is support which we can talk more about in another email.

Figure 1. Genova Diagnostics Adrenal Stress Profile Example

 
But for now, let's go back to the case of Mr Stress yelling his head off. At the end of this commotion things went "all back to normal"  as the  body "recovered until the next stress".

Rest, recovery and replenishment is just soooo important everyone!!! Our ancestors must have faced huge challenges for example when they had to contend with a sabre tooth tiger and decide whether to "fight or flight" or when they had to walk for miles without food until they found a fertile plain. Cortisol prepared them for doing this.

The difference is, our ancestors took the time to rest and recover and also ate a diet, rich in nutrients provided solely by Nature. No HPA Axis dysfunction for them!

These days however, we are faced with a lot more stress both physically and emotionally and this stress is usually of the chronic, underlying type niggling away

Busy lifestyles, stressful jobs, financial worry, illness, allergies and intolerances, menopause (the adrenals pick up the production of cortisol once the ovaries shut down), worry about the future, a lack of sleep (and the fatigue resulting from that), over exercising, under eating, over eating of the quick release energy foods and stimulants such as sugar laden  refined starch, cigarettes, drugs, excess coffee and booze etc.

We have to consider certain major events in our lives like family deaths, divorce, major sickness, rough upbringings, even the health of our own mother during pregnancy... it all contributes along with how much we rest,  how we deal with challenges and how much of a wholesome diet we eat as to the extent our adrenals have been put under stress.


The 3 Stages of Adrenal Fatigue (all happening over months and years, at various lengths and often overlapping)

Stage 1).The first stage of adrenal stress is known as the ‘adaptation phase’. In this state, you will have elevated cortisol levels, you won’t get sick very easily, you may even lose weight due to the adrenal glands releasing sugar stores for use by the muscles. In short you are ‘busy and getting stuff done’. This state will have minimal impact on the body if it only lasts for a couple of weeks, e.g. completing a work project etc. Cortisol is necessary after all - it keeps us strong, alert and able to face up to the challenges in life.
However, if this phase (high cortisol) continues for a long period of time with little or no chance for recovery via rest, you will inevitably enter the next phase sooner or later largely dependent on your genetic disposition.

Stage 2).‘Adrenal fatigue’. When the adrenal glands are fatigued, it literally means they are running out of steam and resources. You are relying more on adrenaline now in times of stress and you will favour being busy as you find it hard to relax, due to feeling ‘wired but tired'.  You will also be more likely to get sick on weekends or on holidays now because when you relax, the usually high adrenaline lowers which leaves the immune system less suppressed and open to more bugs and infections.  So insomnia, poor immunity, digestive issues, bowel function problems, allergies, intolerances, autoimmune conditions and many other conditions you never had any signs of before, but are genetically susceptible to, may also arise here. Of course, these cause more inflammation and stress and the cycle continues.....

It is also at this point that the human body starts to favour stress hormone production over sex hormone production. More of the raw materials necessary for hormone synthesis are invested in the production of cortisol, rather than other hormones necessary for balance - so we are also looking at a decline in testosterone, oestrogen and progesterone levels - therefore a rise in fertility issues and other hormonal imbalances such as bad menopause and thyroid issues.  After all , why would the body want to worry about making babies or keeping trim when stress is rife.! It needs to hold on to what it can! Just as it will hold on to fat also.........

People find they store more fat around the middle also because this is the place where the energy is more readily available for the liver to convert to energy in times of stress and that seems to be quite often. Really, our bodies are only trying to help us survive in a stressful world when it comes to fat storage around the middle.

On the subject of fat around the middle, many ladies find that their waists also widen dramatically when menopause hits... this may be because the adrenal glands have taken over the production of oestrogen from the ovaries, so that's another demand. Oestrogen is also protective for the bones (helps with the absorption of calcium), so , yep, again the ol' body is only trying to help us! With this in mind, fat gain should be expected over the menopause, however, it needs to be around the hips and boobs rather than around the waist. Stress is what makes it primarily store around the middle as opposed to a more even distribution.

Stage 3). Adrenal Exhaustion - cortisol reserves are almost out. Sufferers  have had to leave jobs from nervous breakdown and burnout. They are basically flat liners on the Adrenal Stress Profiles (figure 1), from the moment they wake up, cortisol levels are low where they are supposed to be high in the morning gradually tapering off throughout the day . They have  barely enough energy to get out of bed. This is often seen in states of severe depression, CFS, (Chronic Fatigue Syndrome), ME and Fibromyalgia and in this case, as a nutritional therapist I go straight for adrenal support. I will cover more on adrenal support in an upcoming email.

According to the Mayo Clinic up to 80% of adults have adrenal fatigue at some point in their lives. Have a look at their list of symptoms and see how they relate to this email today and also, if you can relate to any of them. Maybe it's time you took a step away from the over busy world out there, addressed any underlying issues (emotional and physical), gave yourself plenty of rest and relaxation, good food (reduced alcohol!, skipped military boot camp  and adopted a exercise program that suited to your needs.
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  • Fatigue, lethargy:
    • Difficulties getting up in the morning.
    • Lack of energy in the mornings, and also in the afternoon between 3 and 5 pm.
    • Often feel tired between 9 and 10 pm, but resist going to bed.
    • Sleep difficulties.
    • Difficulty concentrating or remembering (brain fog).
  • Need coffee or stimulants to get going in the morning.
  • Feel better suddenly for a brief period after a meal.
  • Cravings for salty, fatty, and high protein food such as meat and cheese.
  • Lowered blood pressure and blood sugar.
  • Lightheadedness (including dizziness and fainting) when rising from a sitting or lying-down position.
  • High frequency of getting the flu and other respiratory diseases -- plus a tendency for them to last longer than usual.
  • Tendency to tremble when under pressure.
  • Pain in the upper back or neck with no apparent reason.
  • Increased symptoms of PMS for women; periods are heavy and then stop, or are almost stopped on the 4th day, only to start flow again on the 5th or 6th day.
  • Reduced sex drive -- particularly in women.
  • Tendency to gain weight and unable to lose it, especially around the waist.
Just as we have to be in tune with our bodies whilst exercising and making nutrition changes, being acutely aware of the subtle messages our bodies send us is a game changer!

Stay relaxed and be one step ahead,

Kim

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Kim Chandler
Nutritional Therapist
07875 163901
www.eatwellandworkout.com


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